研究人员发现了一些人已经发生了极少量的基因变异，这种变异减少了细胞对某种生长激素（即，胰岛素样生长因子1（IGF1)）的使用。
Researchers have discovered that some people have a rare genetic mutation that decreases their cells' use of a particular growth hormone: insulin-like growth factor 1 (IGF1).
这个变异称为IVS5-13insC，造成HMGA1蛋白的功能损伤，HMGA1蛋白是调节胰岛素受体基因（INSR）表达的辅助因子。
The variant, designated IVS5-13insC, impairs function of the HMGA1 protein, a cofactor for gene activation that regulates insulin-receptor gene (INSR) expression.
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