又称脱分化。是指分化细胞失去特有的结构和功能变为具有未分化细胞特性的过程。在动物中, 去分化细胞具有胚胎间质细胞的功能。在植物中, 去分化细胞成为薄壁细胞, 称为愈伤组织(callus)。去分化往往随之又发生再分化(redifferentiation)。
...化和再生转分化(transdifferentiation):一种类型分化的细胞转变成另一种类型的分化细胞现象称转分化。 去分化(dedifferentiation):指分化细胞失去其特有的结构和功能变成具有未分化细胞特征的过程。
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去分化脂肪肉瘤 dedifferentiated liposarcoma ; DDLS
去分化软骨肉瘤 dedifferentiated chondrosarcoma
细胞去分化 Cell Dedifferentiations
分去分化 partial de-differentiation
去分化或异常分化 Dedifferentiation
去分化型软骨肉瘤 Dedifferentiated Chondrosarcoma
去分化骨旁骨肉瘤 dedifferentiated parosteal osteosarcoma ; DDPOS
去分化型脂肪肉瘤 Dedifferentiated liposarcoma
去分化皮质旁骨肉瘤 Dedifferentiated parosteal osteosarcoma ; DD-POS
The phenotypic switch from a quiescent, contractile differentiation state to a highly proliferative, synthetic dedifferentiation state of SMC is believed to contribute to pathogenesis of many SMC-related diseases.
SMC从静止、收缩的分化表型转变为增殖和分泌功能活跃的去分化表型被认为是许多SMC相关疾病重要的发病机制之一。
参考来源 - 胚胎干细胞来源平滑肌细胞的纯化及功能研究Furthermore cells cultured in microcarriercan avoid de-differentiation occurred if we use general cultivation methods. Thephenotype of the cells can be maintained and the quality of the cells will be improvedin the cultivation when the microcarrier suspension culture technique applied.
不仅如此,利用微载体培养细胞可避免普通方法培养细胞时存在的细胞去分化现象,有利于细胞表型的维持,提高细胞的质量。
参考来源 - Vero细胞培养流感病毒的研究·2,447,543篇论文数据,部分数据来源于NoteExpress
重点讨论了去分化与再分化问题。
The discussion was centred on dedifferentiation and redifferentiation.
这样的肿瘤被称为去分化的脂肪肉瘤。
相应的去分化细胞超微结构完整,不损坏。
Correspondingly the ultrastructural integrity of the dedifferentiated cells is less damaged.
So far our ability to de-differentiate cells or find out how to do that is limited.
迄今为止,我们令细胞去分化的能力,和技术方法还相当有限
To find stem cells that they can move from one kind of pathway to another.
去找那些能够,从一种分化途径转到另一种的干细胞
How we could take cells that are differentiated to some extent and make them de-differentiate, to go back in the process of differentiation so that they gain more potential.
我们如何把一些已经分化到,一定程度的细胞去分化,使其回到分化之前,重新获得更多的潜能
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