结论左归丸能改善POF小鼠卵巢免疫性炎症的损伤，对POF具有一定的预防和治疗作用。

Conclusion Zuogui Pill can improve the ovarian injury induced by immune inflammation and has some prevention and treatment action on POF.

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目的探索建立化疗损伤性卵巢功能早衰动物模型的适宜方法及最佳时间。

Objective To investigate an applicable method and optimal time in establishment of the animal model for chemotherapy-induced premature ovarian failure.

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该方法简便易行、造模时间短、成功率高、死亡率低，是建立化疗导致卵巢功能损伤动物模型的较好方法。

It can be used to establish the animal model of chemotherapy-induced ovarian failure due to its simplicity, feasibility, high success rate and low mortality.

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