印记基因是指仅一方亲本来源的同源基因表达,而来自另一亲本的不表达。
文章共同通讯作者剑桥大学的 Ken Ong 博士还表示， 一个引人注目的发现是印记基因(imprinted genes)在其中的作用。印记基因是指只表达亲本一方的遗传信息，而另一方处于关闭状态的一类基因。
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Prader-Willi syndrome (PWS) is an example genetic disorder due to a loss of paternal imprinted gene expression in the 15q11-q13.
PWS是一种由于15q11-q13区域父源性印记基因表达缺陷引起的遗传性疾病。
参考来源 - 眼皮肤白化病Ⅰ型和PraderInpp5f-v3 is a paternally expressed imprinted gene; locate in distal mouse chromosome 7. Inpp5f-v3 is a transcriptional variant of Inpp5f. Inpp5f is an inositol phosphatase gene that is biallelically expressed in the mouse.
Inpp5f-v3(Inositol polyphosphate-5-phosphatase F-variant 3)基因为父本表达的印记基因,定位在鼠7号染色体远端,为Inpp5f基因的一个转录本变体。
参考来源 - 印记基因Inpp5fThese results showed that aberrant reprogramming of DNA methylation occurred in imprinting genes which correlated with development was ubiquitous. Therefore,aberrant DNA methylation may be a reason of the poor profile of SCNT and the organ abnormalities in SCNT bovines.
上述实验结果表明与生长发育密切相关的印记基因DNA甲基化的不完全重编程在体细胞核移植牛中具有一定的普遍性,DNA的异常甲基化会造成印记基因表达紊乱,从而影响个体器官的正常发育,可能是导致克隆效率低下和克隆动物器官发育异常的主要原因之一。
参考来源 - 体细胞核移植牛肺脏中印记基因的DNA甲基化状态分析·2,447,543篇论文数据，部分数据来源于NoteExpress
PEG1在人和鼠上均为母系印记基因。
植物广泛地使用这些表观沉默机制来控制发育及亲本来源的印记基因表达。
Plants use these epigenetic silencing mechanisms extensively to control development and parent-of-origin imprinted gene expression.
现已发现，很多与生长发育密切相关的基因都为印记基因，有些人类疾病如癌症等也都是与基因的异常印记有关。
It was shown that, many genes related to development and growth closely are imprinted genes, and some human disease such as cancers were resulted from the abnormal imprint of some genes.
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