包封率,是指被包裹物质(如某药物)在脂质体悬液中占药物总量的百分量。它是脂质体和纳米粒质量控制的一个重要的指标,反映了药物被载体包封的程度。
包封率(entrapment efficiency)是脂质体包封效果的重要评价指标,如何使脂质体与游离药物得到有效的分离是测定脂质体包封率最为关键的步骤,可根据药物的溶解性、...
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甘草酸脂质体的处方及制备工艺-医药英语-论文中心 Keywords】glycyrrhizicacid;liposome;uniformdesign;encapsulation [gap=203]关键词】甘草酸;脂质体;均匀设计法;包封率
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上海亚荣生化仪器: 白黎芦醇脂质体的制备工艺|精密仪器大全-专业仪器仪表平台 Keywords】 resveratrol; liposomes; entrapment rate; orthogonal design [gap=250]关键词】 白黎芦醇;脂质体;包封率;正交设计
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...存过程中易产生聚集、降解、沉降、融合等作用,造成被包封药物的渗漏,因此在脂质体的研究过程中包封率(encapsulation efficiency,EE)是质量控制的重要指标。当前已有文献报道采用葡聚糖凝胶柱及微柱法测定长春瑞滨脂质体的包封率[4-5]。
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Objective To establish a method for determining the entrapment efficiency of podophyllotoxin in ethosomes.
目的建立鬼臼毒素醇质体包封率的测定方法。
参考来源 - 微柱离心The total alkaloids and adriamycin gelatin microspheres were spherical within 10100 μm particle size distribution(90%). Their drug loading and embedding ratio were 2.56% and 66.44% respectively.
按优化工艺参数制得的载药微球呈圆球形,表面光滑,总载药量为:2.56%,包封率为:66.44%,90%的微球分布在10100μm。
参考来源 - 莲心总碱BACKGROUND: Ethosome is a new liposome with high deformability, high entrapment efficiency and permeating completely through skin. It is especially suitable for the carrier of external administration and cutaneous penetration.
背景:醇质体是一种新型脂质体,具有高变形性、高包封率的优点,能完整地透过皮肤,尤其适合作为外用给药和透皮给药载体。
参考来源 - 苦参碱醇质体的制备及其体外透皮性能The multi-element equation of linear regression were got by statistics soft ware SPSS analyses as follows:Y=48.140-10.370X1-1.600E-02X3+28.364X4-29.196X5,r = 0.915( diameter size); y=-22.761+30.454X1-2.697E-03X3+8.596X4-10.811X5, R=0.946(loading efficiency);y=0.277+0.350X1-2.013E-04X3+9.079E-02X4-0.162X5,R=0.953(drug loading).
利用统计学软件SPSS分析得到的多元线性回归方程如下:y=48.140-10.370X1-1.600E-02X3+28.364X4-29.196X5,r=0.915(粒径);y=-22.761+30.454X1-2.697E-03X3+8.596X4-10.811X5,r=0.946(包封率);y=0.277+0.350X1-2.013E-04X3+9.079E-02X4-0.162X5,r=0.953(载药量)。
参考来源 - 受体介导的粘附粉末制备及其细胞粘附特性的初步研究The diameter of the arbutin liposomes prepared through the new equipment is 70nm and the envelop ratio is 16.532%.
生产的熊菓苷脂质体的粒径为70nm、包封率为16.532%。
参考来源 - β·2,447,543篇论文数据,部分数据来源于NoteExpress
目的测定黄芩苷脂质体的包封率与渗漏率。
Objective To determine the encapsulation efficiency and the release rate of baicalin liposome.
目的制备高包封率的盐酸去氢骆驼蓬碱脂质体。
Objective To prepare a harmine hydrochloride liposome formulation with high encapsulation efficiency.
不同制备条件对微球药物包封率的影响程度较小。
The drug incorporation efficiency was affected in a narrow range by the conditions.
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