通过cdk2磷酸化的cdc6阻止其降解,允许前复制复合体的形成(5)。
Phosphorylation of cdc6 by cdk2 prevents its degradation, allowing pre-replication complexes to form (5).
该复合体也是前复制复合体(pre - RC)的关键组成部分(回顾1)。
This complex is also a key component of the pre-replication complex (pre-RC) (reviewed in 1).
OR c结合DNA后允许其它蛋白如cdc6和MCMs的有序结合,从而形成前复制复合体(Pre - RCs)。
ORC binding to DNA permits the ordered binding of other proteins such as cdc6 and MCMs to form pre-replication complexes (Pre-RCs).
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