尽管人们已为此项研究付出了很大努力，但仍需进行规模要更大、实验设计更优化的研究，以使患者的预后情况达到最佳，并制定出更好的长期随访筛查指南。

Despite intense research efforts, larger studies with improved experimental designs are still needed to maximize patient outcomes and to elucidate better guidelines for long-term screening.

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