分裂原（mitogen）来自植物蛋白或细菌产物，它能与多种细胞膜糖类及寡糖基分子结合，后者为促使丝分裂原受体、结合后能促使细胞活化和诱导细胞分裂。由于细胞膜含有不同糖基，故可认为是多克隆活化剂，它与抗原特异性的克隆活化是不同的
结果VEGF是对内皮细胞特异的有丝分裂原，也有提高血管通透性的作用，在缺氧条件下作用尤为显著。
Results VEGF, as a mitogen specifically for endothelial cells, could strongly stimulate angiogenesis as well as vascular permeability, especially in hypoxia state.
促分裂原活化蛋白激酶（MAPK）级联途径信号通路在真核生物细胞信号的转换和放大过程中起重要作用。
The mitogen-activated protein kinase (MAPK) cascade plays an important role in signal conversion and amplification of extracellular stimuli in eukaryotic organisms.
表皮生长因子受体(EGFR)在人类肝细胞广泛表达，表皮生长因子可能是肝细胞生长中必须的有丝分裂原。
Epidermal growth factor receptor (EGFR) is frequently expressed in human hepatoma cells, and EGF may be one of the mitogens that are needed for the growth of hepatoma cells.
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