记忆力减退、做熟悉的任务出现困难、抽象思考出现问题，这些都是疾病开始的征兆。
Memory loss, difficulty in performing familiar tasks, and problems with abstract thinking are all indicators of the beginning of the disease.
他的热情丝毫没有减退。
他对这些运动项目的兴趣开始减退的同时，对长曲棍球的兴趣却浓厚起来。
While his interest in these sports began to wane, a passion for lacrosse developed.
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