此前FDA共接到因使用肝素而引起上百起不良反应和19起患者死亡报告。
The FDA has received reports of hundreds of reactions and 19 deaths of patients after taking heparin.
结果表明，升高反应温度、以丙酮为共溶剂或以十二烷基硫酸钠作相转移剂均可使反应速度加快。
The results show that increasing reaction temperature, using acetone as cosolvent or sodium dodecyl sulfate as phase-transfer reagent can accelerate the reaction.
加入共溶剂可降低反应苛刻度。
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