克隆清除是指T细胞克隆的TCR对组织特异自身抗原有高亲和力，且浓度高时，经APC提呈，可致此类T细胞克隆清除（deletion)。
未成熟T 细胞通过TCR-CD3 复合物与自身抗原接合激活上述过程可能与克隆清除的形成机制及自我耐受有关。
Activation of this process in immature T cell by the bindng of the TCR CD3 to self antigens may therefor be the mechanism which produces clonal deletion and consequently self tolerance.
胸腺内阴性选择的发生过程也就是中枢免疫耐受的形成过程，即自身反应性胸腺细胞被克隆清除或处于免疫无能状态的过程。
The process of thymic negative selection is the process of the central immunologic tolerance, namely the process of autoreac-tive thymic cells being deleted or becoming allergy.
在有效清除白血病克隆的药物浓度范围内，二者对正常造血干细胞的克隆形成能力无明显影响。
They had no significant effect on the colony-forming capacity of normal hematopoietic stem cells when used at concentrations above.
应用推荐