使生病，使失调，使错乱打乱正常的身体或智能的健康；使神经错乱。

To disturb the normal physical or mental health of; derange .

youdao

战争的压力暂时使他精神错乱。

The stress of war temporarily unhinged him.

《柯林斯英汉双解大词典》

他巨大的青铜雕塑就像从天空中随流星雨一同坠落下来的，使我这样幼稚的人感觉有些笨拙和时空错乱、甚至是粗鄙的。

His huge bronzes seemed to drop from the sky in great meteor showers and felt to my young mind rather clumsy and anachronistic, even provincial.

youdao