首次建立了一种灵敏、简便、准确的采用手性配位交换RP- HPL C与UV联用检测盐酸安妥沙星中对映体杂质的方法。
A sensitive, simple and accurate method for enantiomeric impurity determination of antofloxacin hydrochloride was developed by chiral ligand-exchange RP-HPLC with UV detection.
大位阻取代基有利于提高对映选择性，但位阻过大降低催化活性。
The large steric hindrance group avails to the enantioselectivity, but too much steric hindrance reduces the activity.
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