伤寒杆菌引起的炎症是以巨噬细胞增生为特征的急性增生性炎,增生活跃时巨噬细胞胞浆内吞噬有伤寒杆菌、红细胞和细胞碎片,而吞噬红细胞的作用尤为明显。这种巨噬细胞称为伤寒细胞。伤寒细胞常聚集成团,形成小结节称为伤寒肉芽肿(typhoid granuloma)或伤寒小结(typhoid nodule),是伤寒的特征性病变,具有病理诊断价值。 伤寒细胞伤寒细胞构成:增生的巨噬细胞体积大,吞噬功能十分活跃,胞质内可见被吞噬的伤寒杆菌、红细胞、淋巴细胞和坏死的细胞碎片。见图。
烟草能显著地提高伤寒沙门氏菌突变率和CHO细胞集落形成率;
Tobacco increased significantly the mutation rate of Salmonella typhia and the formation rate of CHO colony.
进行了小白鼠的急性毒性试验、蓄积毒性试验、小白鼠的骨髓细胞微核试验、睾丸染色体畸变试验及鼠伤寒沙门氏菌的致突变试验。
The Study included five experiments, i. e, acute toxicity test and accumulative test of rats, bone-marrow micronucleus test and testis chromosomal aberration test of mouse, and Ames test.
细胞培养人胃癌细胞株BGC823由南京中医药大学伤寒教研室惠赠;
Methods:(1) Cell and cell culture Human gastric carcinoma cell line BGC823 was gifted from the Department of Typhoid of Nanjing University of Traditional ChineseMedicine.
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