阿德福韦是一种单磷酸腺苷的无环核苷类似物,在细胞激酶的作用下被磷酸化为有活性的代谢产物即阿德福韦二磷酸盐。阿德福韦二磷酸盐通过下列两种方式来抑制HBV DNA多聚酶(逆转录酶);一是与自然底物脱氧腺苷三磷酸竞争,二是整合到病毒DNA后引起DNA链延长终止。阿德福韦二磷酸盐对HBV DNA多聚酶的抑制常数(Ki)是0.1μM,但对人类DNA多聚酶α和γ的抑制作用较弱,Ki值分别为1.18μM和0.97μM。
N-溴代丁二酰亚胺 N-Bromosuccinimide ; NBS ; N-Bromosuccinimide extra pure
N-氯代丁二酰亚胺 N-Chlorosuccinimide ; NCS
氯代丁醇 [有化] chlorobutanol
溴代丁二酰亚胺 NBS ; N-Bromosuccinimide
溴代丁二酸 bromosuccinic acid
碘代丁烷 Butyl iodide
羧乙基硫代丁二酸 CETSA
磺代丁二酸二辛钠酯 sodium dioctyl sulphosuccinate
硫代丁酸甲酯 S-methyl butanethioate ; Methyl thiobutyrate
N-碘代丁二酰亚胺 N-Iodosuccinimide
研究了芴与N 溴代丁二酰亚胺(NBS)的光化学反应及其溴代产物的水解反应,提供了一种温和、简便的制备芴醇的方法。
A simple and mild method for the synthesis of fluorenol was studied. 9 bromofluorene (9 BF) can be selectively obtained by the photochemical reaction of fluorene with N bromosuccinimide (NBS).
“我衷心地感激你,我最尽心的朋友,”丁梅斯代尔牧师先生说着,郑重地一笑。
"I thank you from my heart, most watchful friend," said the Reverend Mr. Dimmesdale, with a solemn smile.
还有人宣称,如果丁梅斯代尔先生当真要死,无非是因为这个世界不配他的脚再在上面踩踏。
Some declared, that, if Mr. Dimmesdale were really going to die, it was cause enough, that the world was not worthy to be any longer trodden by his feet.
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