这是他们绝望的标志。

It is a mark of their desperation.

youdao

显然，卜拉欣一家已经等了太久太久，可令他们绝望的事情总是接踵而至。

It's clear that Brahim and his family waited too long, and now things are desperate.

youdao

他们常常陷入孤独、屈辱和绝望的深渊。

They frequently plumb the depths of loneliness, humiliation, and despair.

《柯林斯英汉双解大词典》

But humans continue their violent and evil ways, And in desperation, God wipes them out, and starts again.

但人类继续他们暴力邪恶的行径，绝望时，上帝将他们消灭，重新开始。

耶鲁公开课 - 旧约导论课程节选

They were wandering in the forests and he was in despair, having lost everything.

他们在森林里流浪,那勒陷入绝望,他失去了一切

耶鲁公开课 - 金融市场课程节选