目的建立一种简便、实用的检测亚甲基四氢叶酸还原酶(MTHFR)等位基因C677 T点突变的方法，并初步观察部分健康老人和老年血管性痴呆(VD)患者中mthfr等位基因C677 T点突变情况。

Objective to establish a simple and practical method for detecting the MTHFR gene C677T mutation so as to investigate MTHFR genotypes in the healthy elder and Vascular Dementia (VD).

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按照吸烟特点进行亚组分析：在等位基因比较、纯合子比较、隐性遗传模型和显性遗传模型下，都没有发现吸烟与肺癌有显著关联。

In the subgroup analysis stratified by smoking status, no association of smoking was found between 12139c allele and lung cancer under different genetic models.

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