近年来发现4 -氧代二氢喹啉类和含有非甲基化胞嘧啶鸟嘌呤二核苷酸序列的寡脱氧核苷酸为抗单纯疱疹病毒的新药。
This review describes two kinds of new anti-HSV drugs, 4-oxo-dihydroquinolines and cytosine-phosphate-guanine (CpG) -containing oligodeoxynucleotide (ODN), which have been developed in recent years.
多项研究表明，4 -氧代二氢喹啉类有良好的口服利用率及中等程度的血浆清除率，不仅对核苷酸聚合酶产生抑制，还可以抑制细胞内的病毒复制。
Many studies show that 4-oxo-dihydroquinolines have good oral bioavailability and plasma clearance, and they suppress both the DNA polymerase of HSV and virus replication in the cells.
以邻甲氧基苯酚与对氯*为原料，经四步反应合成6-（2-甲氧苯氧基）-1，4-二氢-4-氧代-3-喹啉羧酸乙酯。经抗鸡球虫实验证明具有抗球虫效果。
The compound 6-(2-methoxy phenoxy)-1, 4-dihydrogen-4-oxo-3-ethyl quinoline carboxylate is prepared with o-methoxyphenol and p-chloronitrobenzene as materials and through four-step reaction.
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