顺乌头酸酶2 (ACO2)在三羧酸循环第二步骤中催化从柠檬酸经顺乌头酸生成异柠檬酸的异构化(1,2)。

Aconitase 2 (ACO2) catalyzes the conversion of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid (TCA) cycle (1, 2).

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结论：纽蛋白和线粒体顺乌头酸酶参与细胞损伤，可能成为神经防护药物作用的靶点。

Conclusion Vinculin and mitochondrial aconitase may be involved in the cytotoxicity, which may be the target of neuroprotective drugs.

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