...是回到治疗前0.3-0.51og以内的病毒量，CD4淋巴球数目回到治疗前数值(baseline values)，或是临床症状恶化(clinical progression)等。(2)出现药物无法忍受或严重的副作用或无法规则服药(nonadherence)。
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主要研究终点的时间从栓塞攻击，栓塞的临床症状恶化科目比例，和安全的症状减轻症状。
Main study endpoints were time to onset of symptom relief from HAE attacks, proportion of subjects with worsening clinical HAE symptoms, and safety.
这三位病人的共同临床症状是，最初发烧、头痛、腹泻和肌痛，接着出现皮疹和肝功能障碍，然后病情迅速恶化和死亡。
Clinical features common to the three patients initially include fever, headache, diarrhoea and myalgia developing into rash and hepatic dysfunction, followed by rapid deterioration and death.
有些病人通常在出现症状后的第5天或者第6天，会遇到临床状况突然快速恶化的情况。
Some of these patients experience a sudden and very rapid deterioration in their clinical condition, usually on day 5 or 6 following the onset of symptoms.
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