二氯醋酸的作用是通过促进一种酶催化丙酮酸进入产能循环过程而重新激活线粒体。
The role of dichloroacetate is to re-activate the mitochondria by stimulating an enzyme that feeds pyruvate into their energy-generating cycle.
低氧条件会直接诱导丙酮酸脱氢酶激酶1 (PDHK1)的表达，它的表达会抑制pdh的活性和TCA循环，从而抑制了随后的代谢通路(4)。
Hypoxia can directly induce pyruvate dehydrogenase kinase 1 (PDHK1) expression, which results in inactivation of PDH and the TCA cycle and subsequent suppression of metabolism (4).
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