他预期最好的药物是一种大蒜提取物，尽管其用于信号干预的主要成分仍然不为所知。
His best bet for a drug lead is an extract of garlic, although the active component that interferes with the signal remains unknown.
然而，糙皮病在当时的美洲几乎还不为人所知，甚至在主要以玉米为生的人之间也是如此。
Pellagra was virtually unknown at that time in the Americas, however, even among people who subsisted primarily on maize.
他们可能不为公众所知，但是也尽其所能地帮助改善人们的生活。
They may not be well-known to the public, but they do what they can to help improve people's lives as well.
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