对于游戏玩家来说，压力是一个大问题。

Stress is a big problem for gamers.

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关键是人们变得不再习惯以一种负责任和独立的方式去思考和行动。其中就存在另一个大问题。

The point is that people grew unaccustomed to thinking and acting in a responsible and independent way. Herein lies another big problem.

《柯林斯英汉双解大词典》

水是一个大问题。

Water is a big problem.

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If it were just a little bit different I could say, all right, I have a different approximation. But when it's this different, something is wrong. Right?

但是如果仅仅有点差异的话,我可以认为没什么大问题,我得到了一个不太一样的估算，但这确实有差异，出问题了对不对？

麻省理工公开课 - 计算机科学及编程导论课程节选

A big problem with this is a lot of Freudian theory is claimed to be validated in the course of psychoanalysis.

这里存在的一个大问题便是,精神分析理论中的很多内容,被认为是能够在精神分析的过程中,得到证实的。

耶鲁公开课 - 心理学导论课程节选

It's going to lead to a lot of interesting things. It's also going to create a really huge problem for monotheistic thought they're going to struggle with for centuries and actually still do struggle with today.

并会引发一系列的有趣事件，它也将给一神论思想,带来一个相当大的问题，这个问题,他们纠结了好几个世纪，直到现在依然存在。

耶鲁公开课 - 旧约导论课程节选