2.7 扭体法(writhing test) 2.7.1 镇痛模型的建立 [22] 建立镇痛模型的要求是:注射一定剂量的镇痛剂,不仅产生的镇痛作用较为 明显,而且对动物的正常活动...
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Methods:Experiments were performed to study the effect of promethazine on the sleeping time of ketamine, the analgesic effect by using hot-plate test and writhing test, and the LD50 by sequential method in mice.
方法:观察异丙嗪对氯胺酮小鼠睡眠时间的影响,用热板法和扭体法观察异丙嗪对氯胺酮镇痛的影响,并以序贯法研究异丙嗪对小鼠氯胺酮LD50的影响。
参考来源 - 异丙嗪对氯胺酮催眠、镇痛作用及LD50的影响—《中国医药导报》—2008年第10期—龙源期刊网3. Writhing test: The mice were divided into six groups randomly: control group, positive drug group ( 300mg/kg) , four herb groups ( 742mg/kg, 1484mg/kg, 2986mg/kg, 5936mg/kg).
3.醋酸致痛扭体实验:小鼠随机分成六组:正常对照组、阳性对照组、中药四个剂量组(742mg/kg、1484mg/kg、2968mg/kg、5936mg/kg)。
参考来源 - 抗感2号解热镇痛作用及其解热机制的实验研究·2,447,543篇论文数据,部分数据来源于NoteExpress
Analgesic action was observed by the methods of hot plate test and writhing test.
采用热板法和扭体法观察骨痛膏的镇痛作用。
Methods The writhing test and the formalin test were performed in order to study the analgesic effect of AMG.
方法利用小鼠福尔马林试验和冰醋酸扭体试验,观察AMG的镇痛效果。
In the writhing test in mice, the MDA con tents in brain, plasma and peritoneal wash fluid also increased significantly.
在扭体试验中,小鼠脑组织、血浆及腹腔灌洗液中MDA含量均有显著增高。
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