The surprise drop in sales compared with last year threw a wrench into the company's fiscal expectations, CEO William L.McCombWilliam L. McComb said.

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Instead, in his prepared remarks, Kindler seems to be emphasizing the drugmaker's ability to wrench big efficiencies out of its enormous structure--a strategy not that different from the cost-cutting going on at rival Merck.

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There's a big monkey wrench in the machinery this year, however.

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