It's important to tighten up the wheels properly, otherwise they vibrate loose and fall off.

把车轮拧紧很重要，否则它们会振动而松脱。

《柯林斯英汉双解大词典》

To evade Mexican police and immigration authorities, the children jump onto and off of the moving train cars. Sometimes they fall, and the wheels tear them apart.

为了躲避墨西哥警察和移民局官员，孩子们在火车行进时上蹿下跳，有时会摔到车底，被车轮碾得粉身碎骨。

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Without her the wheels would fall off this fast moving train.

没有她的车轮脱落，这个快速移动的火车。

youdao

We don't plan to quit until the wheels fall off.

WSJ: Can't Decide Where to Retire?

Williams would eventually cut the Bulls' lead to five again with a transition 3-pointer midway through the fourth, but that was when the wheels began to fall off the Nets' comeback effort.

WSJ: Nets Loss to Bulls Ends Season

However, there also were those who appeared to be tone deaf to the issue, or had already taken a great deal of money just as the wheels were about to fall off of the wagon.

FORBES: Does Your Culture Value a Fair Deal?