We must struggle difficulties.

我们必须与困难作斗争。

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We must struggle with difficulties.

我们必须和困难作斗争。

youdao

To be successful, we must strive, we must struggle.

要想成功，就要努力，就要奋斗。

youdao

We must struggle in our brief existence to find some transcendent meaning during reoccurring heartbreak and disappointment and so find solace in the knowledge that our ancestors have all gone through this before.

NPR: Natural Links in a Long Chain of Being

"There is no alternative to this struggle, which we must win and will win, " said Schroeder after meeting with his security council.

CNN: Europe rallies behind attacks

But we can and must stand with those who so struggle.

WHITEHOUSE: President Obama Addresses the British Parliament