...血管正常化；抗肿瘤免疫 [gap=1247]Key words 】Abnormal angiogenensis; Immunosuppressive microenvironment; Vascular normalization; Anticancer immunotherapy ...
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With the time extended,cells occurred apoptosis or necrosis,and the ability of HUVEC tube formation was weaken. Therefore,the effect of rh-endostatin's vascular normalization might be short-term.4 Simultaneous and docetaxel followed by rh-endostatin administrations exhibited better inhibitory effect on HUVEC tube formation.
但随作用时间延长,其又可诱导细胞凋亡或坏死,管样结构形成能力降低,故恩度的血管正常化作用可能是短期效应。
参考来源 - 恩度对血管内皮细胞的影响及其与多西他赛联合作用的观察·2,447,543篇论文数据，部分数据来源于NoteExpress
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