The drugs were linked to thousands of reports of heart-valve damage as well as cases of a rare but often deadly lung disease.

这两种药物著名的复方减肥药双芬药（fen-phen）的一部分，曾经导致数千例心脏瓣膜损伤，以及数量很少的致命性的肺脏疾病。

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A total of 358 patients with severe aortic stenosis, a heart disease characterized by obstruction of the aortic valve due to calcification, participated in the trial.

总计358名伴严重主动脉瓣狭窄(特征为因钙化主动脉瓣梗阻的一种心脏病)患者参加了这项实验。

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Many research studies have demonstrated that plasma BNP is a marker which plays an important role in the diagnosis, treatment and prognosis of heart valve disease.

许多研究中表明，脑利钠肽作为血浆中重要的标记物，对心脏瓣膜病的诊断、治疗和预后判断等起着非常重要的作用。

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In SEAS, Vytorin failed to do better than placebo at treating a heart valve disease called aortic stenosis, but it did reduce the risk of heart attacks, strokes and operations to unclog arteries.

FORBES: Efficacy Questions Still Dog Vytorin

The insurance company denied the referral, claiming that it would only be appropriate if a diagnosis of heart valve disease had been made.

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Drugs that stimulate the next subtype, the 5-HT2B receptor, have been associated with heart valve disease, the major reason for withdrawal of the fenfluramine part of the fen-phen weight loss combination drug.

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