In fact, improper Forged Steel Valves storage is a major reason for valve damage.

而实际上，保管不当是阀门损坏的重要原因之一。

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In 2006, the warning was upgraded to a black box warning, the FDA's strongest form of warning, because of new data concerning risks of heart valve damage.

2006年，鉴于有新的数据报道有关药物与心脏瓣膜损伤关系，该警示升级为FDA最强烈警告形式—“黑色方框警告”。

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"I know of no evidence that Redux, given by itself, causes heart valve damage, " Wurtman says.

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Its APD356 is far more specific, and so far the heart valve damage that led to fen-phen's withdrawal has not reared its head.

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That's what happened with fen-phen, where Wyeth was swamped with far more expensive cases of heart-valve damage than lawyers--or scientific knowledge--would have suggested was possible.

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