There are several trials on prevention of diabetes with TZDs.

几项临床试验开展了噻唑烷二酮类药物预防糖尿病的研究。

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This result is particularly interesting because in men, loop diuretics or TZDs alone did not confer significant risks.

这一结果特别令人感兴趣，因为男性，单独使用髓袢利尿药或噻唑烷二酮类药物，都不能形成显著的危害。

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Men with diabetes taking both loop diuretics and TZDs may also be at increased risk of fractures, according to the research.

依照这一研究，患有糖尿病的男性在同时服用髓袢利尿药和噻唑烷二酮类药物时也会增加骨折的危险。

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Using cell cultures, the researchers are also discovering how TZDs work on a molecular basis.

BBC: News | Health | Bowel disease drug breakthrough

It is thought that TZDs work by stimulating the production of proteins which block the body's inflammatory response.

BBC: News | Health | Bowel disease drug breakthrough