Is PDGF tyrosine kinase inhibitor effective in pancreatic cancer?

PDGF受体酪氨酸激酶抑制剂在胰腺癌中是否有作用？ ？

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Objective: to review the progress in the research of tyrosine kinase inhibitors in recent years.

目的：对近年来酪氨酸激酶抑制剂的研究进展作以综述。

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The drugs work by preventing an enzyme called tyrosine kinase from launching a signaling cascade that fuels tumor cell growth.

这些药物的作用机制是阻断酪氨酸激酶启动信号级联反应，后者可以促进肿瘤细胞生长。

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Another family is receptor tyrosine kinases, I'll show another picture in a moment that tells you more about what a kinase is, but a kinase is basically an enzyme that can add a phosphorous to another molecule.

另一类是酪氨酸激酶受体,马上我给你们看另一张图,这张图会更详细地告诉你们激酶是什么,激酶是一种能够,向其他分子上添加磷酸基团的酶

耶鲁公开课 - 生物医学工程探索课程节选

In this case, a receptor tyrosine kinase is a receptor molecule that binds a ligand at its surface outside the cell and initiates this enzyme activity - this kinase activity - and causes phosphorylation of another molecule.

在这个例子中,酪氨酸激酶受体可以,在细胞表面区域与配体结合,从而激发出,激酶的活性,使其能够磷酸化另一类分子

耶鲁公开课 - 生物医学工程探索课程节选

What a kinase enzyme does is that it recognizes this protein, and for example, the tyrosine that's on the protein.

激酶能够识别这类蛋白,例如,包含酪氨酸的蛋白

耶鲁公开课 - 生物医学工程探索课程节选

AstraZeneca itself is building an arsenal of anti-cancer pills known as tyrosine kinase inhibitors.

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By 1999 Zeneca had devised a drug, Iressa, that interrupted the pathways between EGF and tyrosine kinase.

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When EGF docks on a receptor, it signals to an enzyme called tyrosine kinase to regulate cell growth.

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