For many, the end of the Lockerbie trial will bring closure - a convenient place from which their lives can move on.

BBC: Living with Lockerbie

Then, in its handling of the RESPECT trial of PFO closure, the company transformed the ideals of research and development into research and denial.

FORBES: 2012 In Review: A Bad Year For Conventional Wisdom

The PC T rial (Clinical Trial Comparing Percutaneous Closure of Patent Foramen Ovale Using the Amplatzer PFO Occluder with Medical Treatment in Patients with Cryptogenic Embolism) randomized 414 patients with PFO who had had an ischemic stroke, TIA, or a peripheral thromboembolic event to either medical therapy or PFO closure with the Amplatzer PFO Occluder.

FORBES: Controversial PFO Closure Trials Published In NEJM