Since diarrhea and skin toxicity limit the use of this drug in some patients, the researchers looked for a specific variation in the ABCG2 gene that could disrupt the function of the ABCG2 protein.

由于腹泻和皮肤毒性限制了此类药物的应用，研究人员期望发现ABCG2基因特异性的突变从而能够阻断ABCG2蛋白的功能。

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Although biodegradation is regarded as an economical and efficacious purified method in the treatment of industry waste water and sewage, the high toxicity of nitrobenzene would limit its application.

虽然生物降解对于工业和生活废水而言是一种经济、有效的净化方法，但在处理硝基苯废水时其高毒性限制了它的使用。

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Then the radiological toxicity of spallation products was studied by applying the concept of annual limit of intake(ALI).

采用年摄入量限值（ALI）标准定义的放射性毒性，对散裂靶中散裂产物产生的放射性毒性进行研究分析。

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