Topical preparations such as creams and gels can cause inflammation, and as this inflammation heals, the skin this gel has been applied to may change pigment over time.
外用制剂，如霜和凝胶，可引起皮肤的炎症。随着炎症的治愈，涂抹在皮肤上的这种凝胶会随着时间的推移改变色素。
Conclusion: Topical use of aciclovir gel on the animal skin is safe.
结论：阿昔洛韦凝胶皮肤局部用药对实验动物较为安全。
OBJECTIVE to prepare the acyclovir ACV palmitate liposome gel in order to raise ACV concentration in the skin and enhance the topical bioavailability of ACV.
目的为了增加阿昔洛韦在皮肤中的滞留量，提高局部生物利用度，制备了阿昔洛韦棕榈酸酯脂质体凝胶剂。
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