Bunions, a genetic condition in which the big toe joint begins to lean inwards and becomes enlarged, can also be triggered by wearing very pointy shoes.

姆囊炎也可能由穿尖头鞋引起，起因是大脚趾关节开始向内倾斜，并且发生肿大。

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Objective to report the clinical results of selective second toe joint transplantation for treatment of interphalangeal and metacarpophalangeal joint defects.

目的探讨不同术式的第二足趾关节移植治疗手指关节、掌指关节不同缺损的疗效。

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In apes the joint surface points in a different direction, so that the big toe can pull away from, and grasp against, the other toes to grip on to tree limbs.

而在猩猩的足部，内侧楔骨的关节面则指向相反方向，将大脚趾从其他脚趾边推开，以便于更好的抓握树干。

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Gout can affect any joint, but classically it appears in the second joint of the big toe.

FORBES: Gout & About: A Slow Walk Through the Northern Quarter

Gout is most commonly associated with pain in the joint of the big toe of middle-aged and older men who are obese, diabetic, hypertensive and drink alcohol, but gout can occur in any joint of adult men and women of any health status and any age.

CNN: Do I have gout or tendinitis?

Investigators recorded 1, 247 gout attacks during the 1-year follow-up period, with 92% occurring in the joint at the base of the big toe.

FORBES: Can Eating Cherries Prevent Gout Attacks?