He had serious problems with his chest and wheezed and coughed all the time.

他胸部有严重问题，总是不停地气喘和咳嗽。

《柯林斯英汉双解大词典》

She brought me a cookie – a Viennese crescent she got from the best bakery in New York – and initiated the first of a life time of serious talks.

她给了我一块饼干——她从纽约最好的面包店买的维也纳式新月形饼干——开始了一生中第一次严肃的谈话。

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During this time, Charlie developed serious problems that were to affect him the rest of his life.

VOA: special.2009.05.03

She lived in New York for a short time, but she was afflicted with lupus, a very serious illness, and she died at the age of 39 in 1964.

她在纽约度过一段短暂的时光，但她饱受狼疮，一种严重疾病的折磨，最终逝世于1964年。

耶鲁公开课 - 1945年后的美国小说课程节选

And it turned out that another, not quite as deadly, but still very serious disease called syphilis was also common in this part of the world at that time.

现在已知另外一种疾病,它并不完全致命但也很严重,它叫梅毒,在那时的一些地方也很常见

耶鲁公开课 - 生物医学工程探索课程节选

On July 30th he announced plans to extend mandatory life sentences to second-time serious violent or sexual offenders, enormously expanding the number of tariff and parole decisions he will have to make.

ECONOMIST: Life sentences

"It's time for serious health professionals to move on and seek solutions that are going to actually curb obesity, " he said.

WSJ: New York City Plans To Restrict Big-Size Soda Sales

An amusing sentiment but at the same time a serious one, and it used to govern the behavior of statesmen overseas, Americans included.

CENTERFORSECURITYPOLICY: Breaching conventions in statesmanship