The invention provides a method for preparing baikal skullcap root chromocor aglycone extract, comprising following steps: disintegrating baikal skullcap root, adding water with amount being 4- 10 times of baikal skullcap root, heating to 40- 70 Deg. C and thermal insulating for 5- 24 hours, enzymolyzing, filtering after reaction, throwing away filtering liquid, extracting dregs of a decoction with ethanol, recovering ethanol, depositing, filtering and drying, getting baikal skullcap root chromocor aglycone extract.

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