Discoveredin 1952, chlorpromazine (Thorazine) wasthe firstantipsychoticmedication. It was used totreatpsychoticdisordersand their symptoms, such ashallucinations, hostility, anddelusions.
The oldest drugs, like Haldol and thorazine, clomp onto the receptor like glue, completely shutting it down so tenaciously that they work for some time after patients stop taking them.