"You can never underestimate anyone, " saidthesecondseed, who attended her news conference wearing a T-shirt emblazoned with the message, "Can't spell dynasty without nasty".
"I had a great week of practice and I was ready to go, " saidthe big-serving Isner, who will be thesecondseed at this week's U.S. Men's Clay Court Championship.
"I stayed aggressive and made sure to have an extra something on my ball, " said fifth seed Sharapova, who will face secondseed Elena Dementieva of Russia in the quarter-finals.