Now he was bitter, gruff, and putting on weight - a big man who had become ponderous, and a pain in the ass: he just rubbed people the wrong way.

现在他变得怨恨，粗暴，而且体重增加，一个很大的人，变得更沉重了，很是让人头痛：他就是把别人推挤错地方了。

youdao

In scientific terms, teenagers can be a pain in the ass. But they are quite possibly the most fully, crucially adaptive human beings around.

从科学角度来看，青少年可能是个讨厌鬼，但他们很可能就是最出色最彻底的环境适应者。

youdao

No request can take more than 30 seconds to run, otherwise it is stopped: Oh my god, this has been a pain in the ass all the time.

没有请求可以超过30秒，否则就被强制断掉。天啊，这是最痛苦的事了。

youdao

As he puts it, 'It's the biggest pain in the ass - you can wait two hours to sit and the staff is hands-down the meanest - but it's most frequently giving you the perfect pizza.

BBC: Where is the US's best pizza?

And actually I became the lead vocal pain in the ass to get things done very different for Bungie.

FORBES: Microsoft "Destroyed" Gaming Startup's Culture

Early on, a very dear friend told me very matter-of-factly to treat this cancer as a pain-in-the-ass inconvenience.

CNN: Sambolin: I feel empowered, supported in cancer fight