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The major side effect observed with Xarelto is bleeding, similar to other anti-clotting drugs.

FORBES: Rivaroxaban Gains FDA Indications For The Treatment And Prevention Of DVT And PE

There's another major side effect to third-party ownership: Its impact on the new Financial Fair Play regulations that limit the losses clubs wishing to play in lucrative European competition can sustain.

WSJ: Third-Party Ownership: How to Stud a Soccer Player

Merck is working on a drug that counteracts a major side effect of Niacin, an HDL-raiser that is already on the market.

FORBES: Magazine Article