The protection and improvement of the human environment is a major issue which affects the well-being of peoples and economic development throughout the world.

人类环境的保护和改善是影响到世界人民幸福和经济发展的主要问题。

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The major issue of contention concerns property rights.

主要的争端还是产权问题。

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The issue of breastfeeding poses a major challenge for many women.

对许多妇女来说，哺乳问题是个严重的挑战。

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To guarantee continued support for the war, Lincoln was forced to recognize that the issue of slavery was, in fact,a major issue.

VOA: special.2009.10.08

In the presidential election of eighteen eighty-eight, one issue that played a major part was tariffs.

VOA: special.2010.05.27

The rebellion in the Philippines became a major issue in America's presidential election of nineteen hundred.

VOA: special.2010.07.29

Education secured its position as the major domestic political issue of the day, and policy makers found themselves engaged in major policy debates over topics ranging from curriculum content and computers in the classroom to vouchers and other new educational delivery systems.

UNESCO: II Part Analytic Section

But at the same time let's not take attention away from the major issue of removing our dependence on fossil fuels.

BBC: A quick fix for global warming

Flanagan is the first openly gay Senate candidate of either major party, and the issue of gay civil unions has been a factor in this race as it has in other statewide contests.

CNN: Both parties vie for control of the Senate