The next year Golde, at the Mayo Clinic, and his collaborator Edward Koo, at uc, San Diego, showed--at least in the test tube--that high doses of ibuprofen and other anti-inflammatories could lower production of amyloid-beta-42, which was believed to be a bad type of amyloid.
"If we could keep people who are still functioning from having any further decline for five years--then they would probably die from something else, " says Todd Golde, a neuroscientist at the Mayo Clinic, in Jacksonville, Fla.