In a 1996 poll of Americans, loss of morality topped the list of the biggest problems facing the U.S.

在1996年的一项针对美国人的民意调查中，道德缺失是美国面临的最大问题。

youdao

One of the biggest problems is pollution.

最大的问题之一是污染。

youdao

There is no doubt that global warming has become one of the biggest problems we face today.

毫无疑问，全球变暖已经成为我们今天面临的最大问题之一。

youdao

For people starting a new business, the biggest problems commonly involve financing.

VOA: special.2009.06.26

So what I would take the most credit for as Chief of Staff is having helped bring in very good, energic, smart, talented people into the White House, into the boarder administration to assist the president on dealing with the biggest problems of the day.

所以我作为办公厅主任最自豪的,就是帮助白宫引进了,非常优秀，非常有活力,非常聪明能干的工作人员,让他们进入这个机构协助总统,处理现今社会的重大问题。

普林斯顿公开课 - 国际座谈会课程节选

"President Obama embodies the new spirit of dialogue and engagement on the world's biggest problems: climate change, nuclear disarmament and a wide range of peace and security challenges,".

VOA: standard.2009.10.09

Dr. JOHN-KALL: The biggest problems that we're seeing currently is the rates of malnutrition.

NPR: Doctor Describes Scene in Darfur

Long waits and lack of information are among the biggest problems for patients in an ER.

NPR: An Emergency Room Built Specially For Seniors

Until now, one of the biggest problems with Enbrel was making enough of it.

FORBES: Amgen, Immunex: The Arthritis Merger