Is that a big problem?

这是个大问题吗？

youdao

Christian in France expressed a different concern, saying: The big problem of the transgenic seeds is that they are the monopoly of big companies.

VOA: special.2010.05.18

That's a big problem and so can you protect these cells that you give to the recipient from attack by the recipient's immune system?

并且至关重要,那么你们想办法保护这些植入受体的细胞,使它们免受免疫系统的排异反应么

耶鲁公开课 - 生物医学工程探索课程节选

That's a big problem a lot, I think in group projects

我觉得这是很多团队项目当中的大问题，

怎么协调意见冲突 - SpeakingMax英语口语达人

None so far has suggested that a big problem exists.

FORBES: Fear And Loathing Along The Hedge Rows

But the initial denial that there was a problem simply became denial that there was a big problem.

FORBES: When You Hear "There's No Problem," Brace Yourself

That is a big problem, and it may be a sign of more trouble to come.

FORBES: Electricity and Gas Markets Are Out Of Synch: Sooner or Later, This Will Hurt Us