Methods Co culture systems of RPE cells with antigen specific t lymphocyte lines and resting t lymphocytes were established in vitro.

方法建立RPE与抗原特异性T淋巴细胞系和静止淋巴细胞之间的共培养系统。

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T cell can only recognize specific antigenic peptide-MHC complex on antigen-presenting cell. This is MHC restriction in antigen recognition of t cell.

细胞只能识别抗原提呈细胞表面特定的抗原肽MHC分子复合物，这就是T细胞抗原识别的MHC限制。

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It has been proved that Dendritic cells (DCs) have strongly ability to present antigen. DCs can trigger t cell responses and enhance the t cell mediated anti tumor effect.

树状突细胞(DC)具有强大的抗原递呈能力，并能有效激发T细胞应答，是目前抗肿瘤免疫治疗研究的热点之一。

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The question is, "If you're naturally exposed to antigen wouldn't this happen anyway?"

她的问题是,在自然条件下,如果接触某种抗原,那么就是否就不发生二次免疫

耶鲁公开课 - 生物医学工程探索课程节选

The other part of the adaptive immune system is the cell mediated immune system and this is an immune where that doesn't involve antibodies but involves cells that are activated in response to a foreign antigen and that utilize cellular means to get rid of it.

获得性免疫系统还包括,细胞免疫,这一免疫反应不包含抗体,但包含可以被激活来应答,并清除外源抗原的免疫细胞

耶鲁公开课 - 生物医学工程探索课程节选

Now, if I was a person that was designing a vaccine and I noticed that this was the response that it got, that antibodies were produced, they reached some intermediate level, they started to fall, I would say, "Well I haven't stimulated the immune system enough, let me re-boost, let me give another dose of antigen."

现在,如果我正在研究一种疫苗,我注意到机体会对这种疫苗产生应答,也就是会产生抗体,当抗体浓度达到中等水平后,就开始下降,就可以说,疫苗对免疫系统刺激还不足,我需要提高抗原浓度,让我再把剂量再加大一倍

耶鲁公开课 - 生物医学工程探索课程节选

Pfizer's drug tremelimumab and Bristol-Myers Squibb's ipilimumab are antibodies to a protein called CTLA-4 (cytotoxic T-lymphocyte antigen-4) that acts as an emergency brake to prevent killer T cells from attacking healthy tissue.

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Both drugs turn off a natural brake on immune system activity called CTLA4 (cytotoxic T-lymphocyte antigen 4).

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However, before the alarm can be sounded in this way, proteins on the surface of the antigen-presenting cell and the T cell must bind together in what is called a cellular handshake.

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