Dexamethasone, a synthetic glucocorticoid, is believed to bind to the glucocorticoid receptors located in the anterior pituitary, thereby reducing ACTH secretion, and ultimately cortisol production.

地塞米松这种人工合成的糖皮质激素，被认为在与位于垂体前叶的糖皮质激素受体结合后使ACTH分泌减少，从而最终导致皮质醇产生减少。

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