By sequencing the LRP6 gene in affected family members, the scientists found that the mutation caused the substitution of a single amino acid in the protein the gene produced.

通过对影响家族成员的LRP6基因测序，科学家发现了突变导致该基因产生的蛋白其中一个氨基酸替换了。

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In the study of mutation mechanism, it was found in 6 cases that there were gains and losses of sites due to nucleotide substitution.

在研究突变机制时，发现有6例由于核苷酸的替换引起了限制性位点的增减。

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The e4. 109 CT substitution was detected in nine swamp buffalo populations, and it was a silent mutation and was not associated with the traits of milk yield in buffalo.

序列分析发现水牛中该外显子的第109位碱基处有C〉T替换，为沉默突变，与泌乳性状之间无显著相关性。

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One concerning mutation, known as "Substitution Q226L, " was found in two of the first three victims.

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