Brought about by the constant pressure of lying on a stationary surface, painful ulcers can involve substantial skin loss, sometimes exposing muscle and even bone.

由于躺在静止的平面上持续产生的压力，疼痛性溃疡会伴随大面积皮肤脱落，有时露出肌肉，甚至骨头。

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Although on the surface the differences between business and consumer marketing may seem obvious, there are more subtle distinctions between the two with substantial ramifications.

尽管表面上企业营销和消费者营销的区别很明显，二者之间存在着更微妙的区别和更重要的分歧。

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The orbiter was commissioned to search for evidence that water persisted on the surface of Mars for a substantial period of time - long enough to provide a habitat for life.

这颗轨道飞行器的任务是在火星表面寻找水的证据，而且水量必须足以为生命栖息地维持相当长一段时间。

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Originally designed as a specialist anti-submarine ship, the Type 22 frigate evolved into a powerful surface combatant with substantial anti-surface, anti-submarine and anti-aircraft weapons systems.

BBC: Navy frigates in Portsmouth 'to be sunk or scrapped'

Originally designed as a specialist anti-submarine ship, the Type 22 frigates evolved into a powerful surface combatant with substantial anti-surface, anti-submarine and anti-aircraft weapons systems.

BBC: Four Royal Navy frigates in Portsmouth Harbour for sale

Sleau Whallian Road and Bayrauye Road, from St Marks to Ballamodha, are both closed due to "substantial damage caused by excessive surface water".

BBC: Isle of Man roads closed by snow and surface water